Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review

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Ovarian Leydig cell tumor is a rare type of ovarian steroid cell neoplasms, presenting in only 0.1% of all ovarian tumor cases, and is generally androgen-secreting COMPLETE COOKIE PEANUT BUTTER and unilateral.Although they are often malignant non-spreading tumors, which have excellent prognosis, benign ovarian Leydig cell tumors with low-risk malignancy can be also detected.Ovarian hyperthecosis is a rare non-neoplastic disorder, in most cases bilateral.

Ovarian tumors and ovarian hyperthecosis are one of the main causes of hyperandrogenism in postmenopausal women, a condition strongly associated with both hormonal and metabolic changes.Here, we report a 65-year-old patient with complaints of excessive body hairiness and alopecia.The laboratory investigation showed increased levels of serum testosterone and dehydroepiandrosterone sulfate (DHEA-S).Imaging, including transvaginal ultrasound and pelvic MRI revealed the presence of two masses in the ovaries.

The patient underwent a laparoscopic bilateral salpingo-oophorectomy due to the ovarian tumors unknown etiology, and histopathological examination revealed a unilateral benign left ovarian Leydig cell tumor with bilateral ovarian stromal hyperplasia and ovarian hyperthecosis.Making differential diagnosis between ovarian Shock tumors and ovarian hyperthecosis is difficult.Bilateral salpingo-oophorectomy is the treatment of choice in postmenopausal women with benign Leydig cell ovarian tumor, as well as ovarian hyperthecosis, as it offers both a cure and diagnostic confirmation.